The Jackson Laboratory

2010

Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW. 2010. Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map. J Bone Miner Res. 25(8):1808-1820.

Beamer WG, Shultz KL, Coombs HF 3rd, Demambro VE, Reinholdt LG, Ackert-Bicknell CL, Canalis E, Rosen CJ, Donahue LR. 2010. BMD regulation on mouse distal Chromosome 1, candidate genes, and response to ovariectomy or dietary fat. J Bone Miner Res. [Epub ahead of print].

Bleich A, Büchler G, Beckwith J, Petell LM, Affourtit JP, King BL, Shaffer DJ, Roopenian DC, Hedrich HJ, Sundberg JP, Leiter EH. 2010. Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity. Inflamm Bowel Dis. 16(5):765-75.

Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, Yang C, Herlihy M, Burzenski L, Gott B, Foreman O, Powers AC, Greiner DL, Shultz LD. 2010. Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2r{gamma}null Ins2Akita Mice. Diabetes [Epub ahead of print].

Brehm MA, Shultz LD, Greiner DL. 2010. Humanized mouse models to study human diseases. Curr Opin Endocrinol Diabetes Obes. 17:120-125.

Brehm MA, Cuthbert A, Yang C, Miller DM, Diiorio P, Laning J, Burzenski L, Gott B, Foreman O, Kavirayani A, Herlihy M, Rossini AA, Shultz LD, Greiner DL. 2010. Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol. 135:84-98.

Bubier JA, Sproule TJ, Alley LM, Webb CM, Fine JD, Roopenian DC, Sundberg JP. 2010. A mouse model of generalized non-herlitz junctional epidermolysis bullosa. J Invest Dermatol. 130(7):1819-28.

Budzynski E, Gross AK, McAlear SD, Peachey NS, Shukla M, He F, Edwards M, Won J, Hicks WL, Wensel TG, Naggert JK, Nishina PM. 2010. Mutations of the opsin gene (Y102H and I307N) lead to light induced degeneration of photoreceptors and constitutive activation of phototransduction in mice. J Biol Chem. 285(19):14521-33.

Bult CJ, Kadin JA, Richardson JE, Blake JA, Eppig JT, Mouse Genome Database G. 2010. The Mouse Genome Database: enhancements and updates. Nucleic Acids Res 38: D586-592.

Chase TH, Lyons BL, Bronson RT, Foreman O, Donahue LR, Burzenski LM, Gott B, Lane P, Harris B, Ceglarek U, Thiery J, Wittenburg H, Thon JN, Italiano JE Jr, Johnson KR, Shultz LD. 2010. The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia. Blood 115(6):1267-76.

Chesler EJ, Baker EJ. 2010. The importance of open-source integrative genomics to drug discovery. Curr Opin Drug Discov Devel. 13(3):310-6.

Demambro VE, Kawai M, Clemens TL, Fulzele K, Maynard JA, Marin de Evsikova C, Johnson KR, Canalis E, Beamer WG, Rosen CJ, Donahue LR. 2010. A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis. J Endocrinol 204:241-253.

Donnelly CJ, McFarland M, Ames A, Sundberg B, Springer D, Blauth P, Bult CJ. 2010. JAX Colony Management System (JCMS): an extensible colony and phenotype data management system. Mamm Genome 21(3-4):205-15.

Driver JP, Scheuplein F, Chen YG, Grier AE, Wilson SB, Serreze DV. 2010. Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. Diabetes 59(2):423-32.

Edwards MM, Mammadova-Bach E, Alpy F, Klein A, Hicks WL, Roux MJ, Simon-Assmann P, Smith RS, Orend G, Wu J, Peachey NS, Naggert JK, Lefebvre O, Nishina PM. 2010. Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation. J Biol Chem. 285:7697-7711.

Gene Ontology Consortium. 2010. The Gene Ontology in 2010: extensions and refinements. Nucleic Acids Res 38: D331-335.

Handel MA, Schimenti JC. 2010. Genetics of mammalian meiosis: regulation, dynamics and impact on fertility. Nat Rev Genet 11:124-136. Review.

Hasham MG, Donghia NM, Coffey E, Maynard J, Snow KJ, Ames J, Wilpan RY, He Y, King BL, Mills KD. 2010. Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat Immunol. [Epub ahead of print].

Hutchins LN, Ding Y, Szatkiewicz JP, Smith RV, Yang H, de Villena FP, Churchill GA, Graber JH. 2010. CGDSNPdb: a database resource for error-checked and imputed mouse SNPs. Database (Oxford) 2010: baq008.

Ingle A, Ghim S, Joh J, Chepkoech I, Jenson AB, Sundberg JP. 2010. Novel Laboratory Mouse Papillomavirus (MusPV) Infection. Vet Pathol. [Epub ahead of print].

Kawai M, Green CB, Lecka-Czernik B, Douris N, Gilbert MR, Kojima S, Ackert-Bicknell C, Garg N, Horowitz MC, Adamo ML, Clemmons DR, Rosen CJ. 2010. A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. Proc Natl Acad Sci USA. 107(23):10508-13.

Kawai M, Green CB, Horowitz M, Ackert-Bicknell C, Lecka-Czernik B, Rosen CJ. 2010. Nocturnin: a circadian target of Pparg-induced adipogenesis. Ann N Y Acad Sci. 1192(1):131-8.

Krebs LT, Starling C, Chervonsky AV, Gridley T. 2010. Notch1 activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants. Genesis 48(3):146-50.

Nicholson A, Reifsnyder PC, Malcolm RD, Lucas CA, Macgregor GR, Zhang W, Leiter EH. 2010. Diet-induced Obesity in Two C57BL/6 Substrains With Intact or Mutant Nicotinamide Nucleotide Transhydrogenase (Nnt) Gene. Obesity (Silver Spring). [Epub ahead of print].

Odgren PR, Pratt CH, Mackay CA, Mason-Savas A, Curtain M, Shopland L, Ichicki T, Sundberg JP, Donahue LR. 2010. Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathies. PLoS One. 5(4): e9959.

Paigen K, Petkov P. 2010. Mammalian recombination hot spots: properties, control and evolution. Nat Rev Genet 11: 221-233. Review.

Parvanov ED, Petkov PM, Paigen K. 2010. Prdm9 controls activation of mammalian recombination hotspots. Science 327:835.

Payne CJ, Gallagher SJ, Foreman O, Dannenberg JH, Depinho RA, Braun RE. 2010. Sin3a is Required by Sertoli Cells to Establish a Niche for Undifferentiated Spermatogonia, Germ Cell Tumors, and Spermatid Elongation. Stem Cells [Epub ahead of print].

Peaston AE, Graber JH, Knowles BB, de Vries WN. 2010. Interrogating the transcriptome of oocytes and preimplantation embryos. Meth Enzymol 477:381-510.

Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ. 2010. High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains. Genes Brain Behav. 9(2):129-59.

Pino S, Brehm MA, Covassin-Barberis L, King M, Gott B, Chase TH, Wagner J, Burzenski L, Foreman O, Greiner DL, Shultz LD. 2010. Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease. Methods Mol Biol 602:105-117.

Robledo RF, Lambert AJ, Birkenmeier CS, Cirlan MV, Cirlan AF, Campagna DR, Lux SE, Peters LL. 2010. Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in {alpha}-spectrin deficient red cells. Blood 115(9):1804-14.

Roopenian DC, Christianson GJ, Sproule TJ. 2010. Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies. Methods Mol Biol 602:93-104.

Saito Y, Kitamura H, Hijikata A, Tomizawa-Murasawa M, Tanaka S, Takagi S, Uchida N, Suzuki N, Sone A, Najima Y, Ozawa H, Wake A, Taniguchi S, Shultz LD, Ohara O, Ishikawa F. 2010. Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells. Sci Transl Med 2: 17ra19.

Saito Y, Uchida N, Tanaka S, Suzuki N, Tomizawa-Murasawa M, Sone A, Najima Y, Takagi S, Aoki Y, Wake A, Taniguchi S, Shultz LD, Ishikawa F. 2010. Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. Nat Biotechnol. 28:275-280.

Scheuplein F, Rissiek B, Driver JP, Chen YG, Koch-Nolte F, Serreze DV. 2010. A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes. J Autoimmun. 34(2):145-54.

Shultz LD, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M, Doi T, Sone A, Suzuki N, Fujiwara H, Yasukawa M, Ishikawa F. 2010. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r{gamma}null humanized mice. Proc Natl Acad Sci USA 107(29):13022-7.

Spindler KR, Welton AR, Lim ES, Duvvuru S, Althaus IW, Imperiale JE, Daoud AI, Chesler EJ. 2010. The major locus for mouse adenovirus susceptibility maps to genes of the hematopoietic cell surface-expressed LY6 family. J Immunol. 184(6):3055-62.

Su YQ, Sugiura K, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ. 2010. Mouse Oocytes Enable LH-Induced Maturation of the Cumulus-Oocyte Complex via Promoting EGF Receptor-Dependent Signaling. Mol Endocrinol. 24(6):1230-9.

Su Z, Leduc MS, Korstanje R, Paigen B. 2010. Untangling HDL QTL on mouse chromosome 5 and identifying Scarb1 and Acads as the underlying genes. J Lipid Res. [Epub ahead of print].

Sun F, Palmer K, Handel MA. 2010. Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes. Development 137(10):1699-707.

Varlakhanova NV, Cotterman RF, deVries WN, Morgan J, Donahue LR, Murray S, Knowles BB, Knoepfler PS. 2010. myc maintains embryonic stem cell pluripotency and self-renewal. Differentiation 80(1):9-19.

Xu J, Krebs LT, Gridley T. 2010. Generation of mice with a conditional null allele of the Jagged2 gene. Genesis 48(6):390-3.

Zhang B, Strauss AC, Chu S, Li M, Ho Y, Shiang KD, Snyder DS, Huettner CS, Shultz L, Holyoake T, Bhatia R. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 17(5):427-42.

Zhao L, Rosales C, Seburn K, Ron D, Ackerman SL. 2010. Alteration of the Unfolded Protein Response Modifies Neurodegeneration in a Mouse Model of Marinesco-Sjogren Syndrome. Hum Mol Genet 19:25-35.

2009

Burgess-Herbert SL, Tsaih SW, Stylianou IM, Walsh K, Cox AJ, Paigen B. 2009. An experimental assessment of in silico haplotype association mapping in laboratory mice. BMC Genet 10:81.

Byers SL, Wiles MV, Taft RA. 2009. Surgical oocyte retrieval (SOR): a method for collecting mature mouse oocytes without euthanasia. J Am Assoc Lab Anim Sci 48:44-51.

Cimino JJ, Hayamizu TF, Bodenreider O, Davis B, Stafford GA, Ringwald M. 2009. The caBIG terminology review process. J Biomed Inform 42:571-580.

Cox A, Ackert-Bicknell CL, Dumont BL, Ding Y, Bell JT, Brockmann GA, Wergedal JE, Bult C, Paigen B, Flint J, Tsaih SW, Churchill GA, Broman KW. 2009. A new standard genetic map for the laboratory mouse. Genetics 182:1335-1344.

Dolan M, Blake J. 2009. Using ontology visualization to facilitate access to knowledge about human disease genes. Applied Ontology 4:35-49.

Dowell KG, McAndrews-Hill MS, Hill DP, Drabkin HJ, Blake JA. 2009. Integrating text mining into the MGI biocuration workflow. Database (Oxford) 2009: bap019.

Evsikov AV, Dolan ME, Genrich MP, Patek E, Bult CJ. 2009. MouseCyc: a curated biochemical pathways database for the laboratory mouse. Genome Biol 10: R84.

Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. 2009. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392-395.

Hibbs M, Myers C, Huttenhower C, Hess D, Li K, Caudy A, Troyanskaya O. 2009. Directing Experimental Biology: A Case Study in Mitochondrial Biogenesis. PLoS Comput Biol 5: e100322-e100344.

La Salle S, Sun F, Handel MA. 2009. Isolation and short-term culture of mouse spermatocytes for analysis of meiosis. Methods Mol Biol 558:279-297.

Leiter EH. 2009. Selecting the "right" mouse model for metabolic syndrome and type 2 diabetes research. Methods Mol Biol 560:1-17.

Lomeli H, Starling C, Gridley T. 2009. Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects. BMC Res Notes 2:22.

Luo L, Gassman KL, Petell LM, Wilson CL, Bewersdorf J, Shopland LS. 2009. The nuclear periphery of embryonic stem cells is a transcriptionally permissive and repressive compartment. J Cell Sci 122:3729-3737.

Ng SH, Maas SA, Petkov PM, Mills KD, Paigen K. 2009. Colocalization of somatic and meiotic double strand breaks near the Myc oncogene on mouse chromosome 15. Genes Chromosomes Cancer 48:925-930.

Ng SH, Madeira R, Parvanov ED, Petros LM, Petkov PM, Paigen K. 2009. Parental origin of chromosomes influences crossover activity within the Kcnq1 transcriptionally imprinted domain of Mus musculus. BMC Mol Biol 10:43.

Parvanov ED, Ng SHS, Petkov PM, Paigen K. 2009. Trans-regulation of mouse meiotic recombination hotspots by Rcr1. PLoS Biol 7: e1000036.

Reinholdt LG, Czechanski A, Kamdar S, King BL, Sun F, Handel MA. 2009. Meiotic behavior of aneuploid chromatin in mouse models of Down syndrome. Chromosoma 118:723-736.

Rice RH, Rocke DM, Tsai HS, Silva KA, Lee YJ, Sundberg JP. 2009. Distinguishing Mouse Strains by Proteomic Analysis of Pelage Hair. J Invest Dermatol. 199:2120-2125.

Rodilla V, Villanueva A, Obrador-Hevia A, Robert-Moreno A, Fernandez-Majada V, Grilli A, Lopez-Bigas N, Bellora N, Alba MM, Torres F, Dunach M, Sanjuan X, Gonzalez S, Gridley T, Capella G, Bigas A, Espinosa L. 2009. Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A 106:6315-6320.

Salisbury J, Hutchison KW, Wigglesworth K, Eppig JJ, Graber JH. 2009. Probe-level analysis of expression microarrays characterizes isoform-specific degradation during mouse oocyte maturation. PLoS One 4: e7479.

Shockley KR, Witmer D, Burgess-Herbert SL, Paigen B, Churchill GA. 2009. Effects of atherogenic diet on hepatic gene expression across mouse strains. Physiol Genomics 39:172-182.

Singh P, Alley TL, Wright SM, Kamdar S, Schott W, Wilpan RY, Mills KD, Graber JH. 2009. Global changes in processing of mRNA 3' untranslated regions characterize clinically distinct cancer subtypes. Cancer Res 69:9422-9430.

Smith CL, Eppig JT. 2009. The Mammalian Phenotype Ontology: enabling robust annotation and comparative analysis. Wiley Interdiscip Rev Syst Biol Med 1: 390-399. PMCID: PMC2801442.

Smith R, Sheppard K, DiPetrillo K, Churchill G. 2009. Quantitative trait locus analysis using J/qtl. Methods Mol Biol 573:175-188.

Su Z, Cox A, Shen Y, Stylianou IM, Paigen B. 2009. Farp2 and Stk25 are candidate genes for the HDL cholesterol locus on mouse chromosome 1. Arterioscler Thromb Vasc Biol 29:107-113.

Su Z, Wang X, Tsiah S-W, Zhang A, Cox A, Sheehan S, Paigen B. 2009. Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res 50:116-125.

Sugiura K, Su YQ, Eppig JJ. 2009. Targeted suppression of Has2 mRNA in mouse cumulus cell-oocyte complexes by adenovirus-mediated short-hairpin RNA expression. Mol Reprod Dev 76:537-547.

Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ. 2009. Fibroblast Growth Factors and Epidermal Growth Factor Cooperate with Oocyte-Derived Members of the TGFbeta Superfamily to Regulate Spry2 mRNA Levels in Mouse Cumulus Cells. Biol Reprod 81:833-841.

Sundberg BA, Schofield PN, Gruenberger M, Sundberg JP. 2009. A data-capture tool for mouse pathology phenotyping. Vet Pathol 46:1230-1240.

Sundberg JP, Schofield PN. 2009. One medicine, one pathology, and the one health concept. J Am Vet Med Assoc 234:1530-1531.

Sundberg JP, Ward JM, Schofield P. 2009. Where's the mouse info? Vet Pathol 46:1241-1244.

The Reference Genome Group of the Gene Ontology Consortium (including Blake JA). 2009. The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species. PLoS Comput Biol 5: e1000431.

Tsaih SW, Korstanje R. 2009. Haplotype association mapping in mice. Methods Mol Biol 573:213-222.

Unsinger J, McDonough JS, Shultz LD, Ferguson TA, Hotchkiss RS. 2009. Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol 86:219-227.

Verdugo RA, Deschepper CF, Munoz G, Pomp D, Churchill GA. 2009. Importance of randomization in microarray experimental designs with Illumina platforms. Nucleic Acids Res 37:5610-5618.

Wang Y, Zheng Y, Nishina PM, Naggert JK. 2009. A new mouse model of metabolic syndrome and associated complications. J Endocrinol 202:17-28.

Wright SM, Woo YH, Alley TL, Shirley BJ, Akeson EC, Snow KJ, Maas SA, Elwell RL, Foreman O, Mills KD. 2009. Complex oncogenic translocations with gene amplification are initiated by specific DNA breaks in lymphocytes. Cancer Res 69:4454-4460.

Yang H, Ding Y, Hutchins LN, Szatkiewicz J, Bell TA, Paigen BJ, Graber JH, de Villena FP, Churchill GA. 2009. A customized and versatile high-density genotyping array for the mouse. Nat Methods 6:663-666.

Yuan R, Tsaih SW, Petkova SB, de Evsikova CM, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B. 2009. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 8:277-287.