Datasets
- QTL mapping
- Gene expression
QTL Archive
Welcome to the QTL Archive!
This site provides access to raw data from various QTL (quantitative trait loci) studies using rodent inbred line crosses. Most data are available in the .csv fromat used by R/qtl and pseudomarker programs. In some cases analysis scripts and/or results are posted to accompany the data.
These data are provided as a courtesy to the genetic mapping community and may be used for purposes of developing or testing new analysis methods or software and for meta-analysis of quantitative traits. The authors of the datasets retain individual ownership of the data. We request, as a courtesy to the authors, that you alert them in advance of any publications that result from reanalysis of these data or obtain permission prior to redistribution of data or results.
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Submit your data
Click here to submit your data.
Usage notes:
Warranty Disclaimer and Copyright Notice.
CSV data format used in the QTL archive dataset.
Pseudomarker data format used in the QTL Archive by Genevieve Monsees.
Pseudomarker introduction by Genevieve Monsees and Saunak Sen.
Datasets available:
- Beamer WG, Shultz KL, Churchill GA, Frankel WN, Baylink DJ, Rosen CJ, Donahue LR. 1999. Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Mamm Genome 10(11):1043-1049.
- Reifsnyder PC, Churchill GA, Leiter EH. 2000. Maternal environment and genotype interact to establish diabesity in mice. Genome Res 10(10):1568-1578.
- Guay-Woodford LM, Wright CJ, Walz G, Churchill GA. 2000. Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model. J Am Soc Nephrol 11:1253-1260.
- Clemens KE, Churchill GA, Bhatt N, Richardson K, Noonan FP. 2000. Genetic control of susceptibility to UV-induced immunosuppression by interacting quantitative trait loci. Genes and Immunity 1:251-259.
- Sugiyama F, Churchill GA, Higgins DC, Johns C, Makaritsis KP, Gavras H, Paigen B. 2001. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics 71:70-77.
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- Shimomura K, Low-Zeddies SS, King DP, Steeves TDL, Whitely A, Kushla J, Zemenides PD, Lin A, Vitaterna MH, Churchill GA, Takahashi JS. 2001. Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice. Genome Res 11:959-980.
- Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ. 2001. Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res 16(7):1195-1206.
- Farmer MA, Sundberg JP, Bristol IJ, Churchill GA, Li R, Elson CO, Leiter EH. 2001. A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice. Proc Natl Acad Sci USA 98(23):13820-13825.
- Smith Richards BK, Belton BN, Poole AC, Mancuso JJ, Churchill GA, Li R, Volaufova J, Zuberi A, York B.. 2002. QTL analysis of self-selected macronutrient diet intake: fat, carbohydrate, and total kilocalories. Physiol Genomics 11:205-217.
- Sundberg JP, Boggess D, Silva K, McElwee KJ, King LE, Li R, Churchill GA, Cox GA. 2003. Major locus on mouse chromosome 17 and minor locus on chromosome 9 are linked with alopecia areata in C3H/HeJ mice. J Investigative Dermatology 120:1-5.
- Brich J, Shie F-S, Howell BW, Li R, Tus K, Wakeland EK, Jin L-W, Mumby M, Churchill GA, Herz J, Cooper JA. 2003. Genetic modulation of tau phosphorylation in the mouse. J Neurosci 23(1):187-192.
- Sugiyama F, Churchill GA, Li R, Libby LJM, Carver T, Yagami K-I, John SWM, Paigen B. 2002. QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice. Physiol Genomics 10:5-12.
- Pitman WA, Korstanje R, Churchill GA, Nicodeme E, Albers JJ, Cheung MC, Staton MA, Sampson SS, Harris S, Paigen B. 2002. Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice. Physiol Genomics 9:93-102.
- Mahler M, Most C, Schmidtke S, Sundberg JP, Li R, Hendrich HJ, Churchill GA. 2002. Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis. Genomics 80(3):274-282.
- Wittenburg H, Lammert F, Wang DHQ, Churchill GA, Li R, Bouchard G, Carey MC, Paigen B. 2001. Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice. Physiol Genomics 8:67-77.
- Lyons MA, Wittenburg H, Li R, Walsh KA, Churchill GA, Carey MC, Paigen B. 2003. Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice. J Lipid Res 44:953-967.
- Wang X, Le Roy I, Nicodeme E, Li R, Wagner R, Petros C, Churchill GA, Harris S, Darvasi A, Kirilovsky J, Roubertoux PL, Paigen BJ. 2003. Using Advanced Intercross Lines for High-Resolution Mapping of HDL Cholesterol Quantitative Trait Loci. Genome Res 13(7):1654-1664.
- Rosen CJ, Churchill GA, Donahue LR, Shultz KL, Burgess JK, Powell DR, Beamer WG. 2000. Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice. Bone 27:521-528.
- Lyons MA, Wittenburg H, Li R, Walsh KA, Leonard MR, Churchill GA, Carey MC, Paigen BJ. 2003. New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice. Physiol Genomics 14:225-239.
- Lyons MA, Wittenburg H, Li R, Walsh KA, Leonard MR, Korstanje R, Churchill GA, Carey MC, Paigen BJ. 2003. Lith6: a new QTL for cholesterol gallstones from an intercross of CAST/Ei and DBA/2J inbred mouse strains. J Lipid Res 44:1763-1771.
- Wittenburg H, Lyons MA, Li R, Churchill GA, Carey MC, Paigen BJ. 2003. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology 125:868-881.
- Nadeau JH, Burrage LC, Restivo J, Pao Y-H, Churchill GA, Hoit BD. 2003. Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populations. Gen Res 13:2082-2091.Download Dataset
- Lyons MA, Korstanje R, Li R, Walsh KA, Churchill GA, Carey MC, Paigen BJ. 2004. Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS/J inbred mice. Physiol Genomics 17:114-121.
- Lyons MA, Wittenburg H, Li R, Walsh KA, Korstanje R, Churchill GA, Carey MC, Paigen BJ. 2004. Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CASTE/Ei inbred mice. Physiol Genomics 17:60-68.
- Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B. 2004. Quantitative trait loci analysis for plasma HDL-cholesterol concentrations and atherosclerosis susceptibility between inbred mouse strains C57BL/6J and 129S1/SvImJ. Arterioscler Thromb Vasc Biol 24:161-166.
- DiPetrillo K, Tsaih SW, Sheehan S, Johns C, Kelmenson P, Gavras H, Churchill, GA, Paigen B. 2004. Genetic analysis of blood pressure in C3H/Hej and SWR/J mice. Physiol Genomics 17(2):215-220.
- Ahmadiyeh N, Churchill GA, Shimomura K, Solberg LC, Takahashi JS, Redei EE. 2003. X-Linked and lineage dependent inheritance of coping response to stress. Mamm Genome 14:748-757.
- Peters LL, Swearingen RA, Andersen SG, Gwynn B, Lambert AJ, Li R, Lux SE, Churchill GA. 2004. Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency. Blood 103(8):3233-3240.
- Korstanje R, Li R, Howard T, Kelmenson P, Marshall J, Paigen BJ, Churchill GA. 2004. Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BINJ intercross population. J Lipid Res 45:881-888.
- Stylianou IM, Tsaih SW, DiPetrillo K, Ishimori N, Li R, Paigen BJ, Churchill GA. Complex Genetic Architecture Revealed by Analysis of HDL in Chromosome Substitution Strains and F2 Crosses.
Please direct comments about this web site to PI: Gary Churchill or Web Master: Meher Parveen.
