Welcome

We are developing statistical and computational tools for investigations of genetics and molecular biology. We would like to understand how natural genetic variation determines phenotypic variation in higher organisms.

Our goal is to make it possible to analyze the simultaneous actions of multiple genes and their joint role in whole organism biology. As we unravel the genetic networks and pathways of a physiological process, we can also identify where the natural variants within the pathways reside. 

Please cite this page as http://research.jax.org/faculty/churchill/.

Announcements

  1. Carl Zimmer, the science reporter who wrote the Discover magazine story on the Lab's approach to understanding complex genetic traits, wrote a fascinating blog entry that goes into greater detail on this subject. (05/24/2007)
  2. The Discover article "Inside the Lab-Mouse Factory" was just posted today on their website even though the magazine has been out for a month. (05/24/2007)
  3. R/maanova-1.4.1 released for fixing the problem of La.svd() in R base package. (4/17/2007)
  4. J/qtl 0.9-070402 released with few bug fixes. (4/02/2007)
  5. R/maanova-1.2.2 released for R-2.3.1 and ealier for avoiding the problem in La.svd(). (3/21/2007)
  6. J/qtl 0.9-070228 released with few bug fixes and improvements. This version of J/qtl works with R-2.4.1. (02/28/2007)
  7. J/qtl 0.9. Works with current R/qtl 1.05-2 and R-2.4.0 (12/26/2006)
  8. J/qtl 0.8. The newest release of this Java GUI for R/qtl. (5/10/2006).
  9. Pseudomarker 2.03. This is our newest release of pseudomarker software (11/30/2005).
  10. The Collaborative Cross, a community resource for the genetic analysis of complex traits. The current issue of Nature Genetics features a Commentary by the Complex Trait Consortium. The Consortium, a large international group of researchers led by Senior Staff Scientist Gary Churchill, proposes to develop a Collaborative Cross--a large collection of recombinant inbred mouse strains--in order to more efficiently identify study the genetics of complex traits. (Dr. Churchill explains: "In a nutshell, the proposal is to take eight existing strains of mice, carefully selected for maximal diversity, and to shuffle their genomes together like a deck of cards. The result will be 1,000 new strains of mice that can be mated to produce as many as one million genetic combinations, providing a wealth of new models for human diseases.")
  11. Submit your QTL experiment data here. We will post them on QTL archive page (11/18/2004).
  12. Older announcements.

Please direct comments about this web site to nazira.bektassova@jax.org