Gerontology References

Chen J, Astle CM, Harrison DE. 2003. Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction. Exp Hematol. 31:1097-1103.

Chesler EJ, Miller DR, Branstetter LR, Galloway LD, Jackson BL, Philip VM, Voy BH, Culiat CT, Threadgill, DW, Williams RW, Churchill GA, Johnson DK, Manly KF. 2008. The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics. Mamm Genome 19:382-389.

Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, et al. 2004. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet 36(11):1133-1137.

Ertl RP, Chen J, Astle CM, Duffy TM, Harrison DE. 2008. Effects of dietary restriction on hematopoietic stem cell aging are genetically regulated. BLOOD. Oct 19 111(3):1709-1716.

Ertl RP, Harrison DE. 2008. Dietary restriction: a model system probing the cell fate decision between cancer and senescence. In: Mouse Models of Human Blood Cancers: Basic Research and Pre-Clinical Applications. Li S, (ed). Chapter 6, pp. 133-156. Springer.

Flurkey K, Astle CM, Harrison DE. 2010. Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 65(12):1275-84.

Flurkey K, Brandvain Y, Klebanov S, Austad SN, Miller RA, Yuan R, Harrison DE. 2007. PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span. J Gerontol A Biol Sci Med Sci 62:1187-1198.

Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. 2001. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci USA 98:6736Ñ6741.

Flurkey K. Papaconstantinou J, Harrison DE. 2002. The Snell dwarf mutation Pit1(dw) can increase life span in mice. Mech Ageing Dev 123:121-130.

Harrison DE, Archer JR, Astle CM. 1982. The effect of hypophysectomy on thymic aging in mice. J Immunol 129:2673-7.

Harrison DE, Archer JR, Astle CM. 1984. Effects of food restriction on aging: separation of food intake and adiposity. Proc Natl Acad Sci USA 81:1835-8.

Harrison DE, Archer JR, Kent B. 1991. Genes regulate effects of dietary restriction. In: Biological Effects of Dietary Restriction, Fishbein L (ed), Springer-Verlag, pp. 264-86.

Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors M, Fernandez E, Miller RA. 2009. Rapamycin fed from 20 months of age extends lifespan in genetically heterogeneous mice. Nature. 460:392-395.

Klebanov SE, Harrison DE. 2002. Optimizing detection of QTLs retarding aging: choice of statistical model and animal requirements. Mech Ageing Dev 123:131-144.

Klebanov SE, Astle CM, Roderick TH, Flurkey K, Archer JR, Chen J, Harrison DE. 2001. Maximum life spans in mice are extended by wild strain alleles. Exp Biol Med 226(9):854-859.

Miller RA, Austad S, Burke D, Chrisp C, Dysko R, Galecki A, Jackson A, Monnier V. 1999. Exotic mice as models for aging research: polemic and prospectus. Neurobiol Aging 20:217-231.

Regelson W. 1983. The evidence for pituitary and thyroid control of aging: Is age reversal a myth or reality?! The search for a "death" hormone. In "Intervention in the Aging Process, Part B: Basic Research and Preclinical Screening," pp. 3-52, Alan R. Liss, Inc., New York.

Roberts A, Pardo-Manuel de Villena F, Wang W, McMillan L, Threadgill DW. 2007. The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics. Mamm Genome 18(6-7):473-481.

Yuan R, Flurkey K, Van Aelst-Bouma R, Zhang W, King B, Austad S, Miller RA, Harrison DE. 2006. Altered growth characteristics of skin fibroblasts from wild-derived mice, and genetic loci regulating fibroblast clone size. Aging Cell 5:203-212.

Zhao H, Nettleton D, Soller M, Dekkers JC. 2005. Evaluation of linkage disequilibrium measures between multi-allelic markers as predictors of linkage disequilibrium between markers and QTL. Genet Res 86(1):77-87.

Note: For a complete list of publications from the Harrison Laboratory, please visit Harrison Publications.

Site last updated January 23, 2012.