Biomarker data: effects of biomarker testing on life span
Table VI.5 provides 2 comparisons: 1) mice that were "Tested" vs. mice that were "Not tested"; 2) "Not tested" mice identified as moribund and necropsied vs. "Not necropsied" mice that were found dead and not necropsied. This second comparison indicates the accuracy of being able to identify old mice just before they die. For a list of the biomarker tests used, see Table VI.7, Biomarker test results at 495 days.
Table VI.5. Effects of biomarker testing on life span; the accuracy of identifying mice as moribund.
|
SEX |
MEDIAN |
MEAN |
SE |
N |
LAST 10% | ||
|
C57BL/6J |
M |
|
|
|
|
| |
|
Tested |
913 |
905 |
19 |
29 |
1031-1035 | ||
|
Not tested |
948 |
899 |
37 |
26 |
1112-1163 | ||
|
Not necropsied |
875 |
866 |
24 |
42 |
1082-1166 | ||
|
|
|
|
|
|
|
| |
|
C57BL/6J |
F |
|
|
|
|
| |
|
Tested |
869 |
844 |
26 |
34 |
1013-1077 | ||
|
Not tested |
793 |
818 |
29 |
28 |
1048-1076 | ||
|
Not necropsied |
849 |
827 |
23 |
40 |
1026-1149 | ||
|
|
|
|
|
|
|
| |
|
CBA/H-T6J |
M |
|
|
|
|
| |
|
Tested |
833 |
827 |
26 |
32 |
1023-1079 | ||
|
Not tested |
932 |
907 |
28 |
23 |
1092-1101 | ||
|
Not necropsied |
953 |
910 |
26 |
37 |
1119-1164 | ||
|
|
|
|
|
|
|
| |
|
CBA/H-T6J |
F |
|
|
|
|
| |
|
Tested |
954 |
927 |
22 |
31 |
1070-1119 | ||
|
Not tested |
960 |
956 |
29 |
24 |
1160-1160 | ||
|
Not necropsied |
1002 |
989 |
31 |
38 |
1203-1275 | ||
|
|
|
|
|
|
|
| |
|
B6CBAT6F1 |
M |
|
|
|
|
| |
|
Tested |
931 |
933 |
33 |
32 |
1179-1298 | ||
|
Not tested |
1063 |
1065 |
46 |
20 |
1283-1326 | ||
|
Not necropsied |
1009 |
997 |
30 |
41 |
1257-1309 | ||
|
|
|
|
|
|
|
| |
|
B6CBAT6F1 |
F |
|
|
|
|
| |
|
Tested |
967 |
971 |
25 |
31 |
1139-1210 | ||
|
Not tested |
983 |
969 |
30 |
23 |
1163-1274 | ||
|
Not necropsied |
981 |
982 |
22 |
43 |
1177-1331 | ||
Mice in good health at 480 days of age, when study began. Tested = non-lethal biomarker test battery at 16 and 22 months of age; necropsied when moribund. Not tested = unused, but necropsied when moribund. Not necropsied = unused. Both practice and demonstrated expertise are required to recognize when mice are moribund.
Table VI.6. Effects of biomarker testing (at 495 and 675 days) on life spans of mice.
| STRAIN | SEX | MEAN | MEDIAN | STDEV | N | RANGE LAST 10% | |
| C57BL/6J | M | 874.3 | 888 | 144.9 | 84 | 1045-1269 | |
| F | 835.0 | 852 | 153.4 | 85 | 1019-1104 | ||
| CBA/CAJ | M | 811.0 | 823 | 150.6 | 22 |
1014 |
|
| F | 917.5 | 911 | 145.6 | 22 | 1131-1139 | ||
| CBA/H-T6J | M | 850.3 | 858 | 157.9 | 88 | 1060-1094 | |
| F | 880.4 | 911 | 166.1 | 87 | 1067-1174 | ||
| B6CBAF1 | M | 922.0 | 927 | 180.4 | 23 | 1192-1276 | |
| F | 878.1 | 880 | 158.1 | 23 | 1127-1291 | ||
|
B6CBAT6F1 |
M |
945.0 |
969.5 |
207.6 |
86 |
1195-1325 |
|
| F | 880.4 | 911 | 166.1 | 87 | 1069-1174 | ||
This table does not include mice with life spans less than 495 days.
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Site last updated September 13, 2008.
