Treatment data: activated lipid (HDL and LDL)


Table VI.9. C57BL/6J males and B6CBAT6F1 females: changes in weight among activated lipid fed, control, and colony control mice.

C57BL/6J Males
Activated Lipid Control Colony Control
Age
Group (days)
X SE N X SE N X SE N
30 Y 22.1 0.3 36
60 Y 23.6 0.4 12 26.3 0.4 12
90 Y 27 0.5 12 27.8 0.3 12 29.2 0.4 36
164 Y 29.8 0.7 12 30.4 0.6 12
210 Y 32.7 0.9 12 33.5 0.8 12 33.4 2.2 36
860 O 34.6 0.5 14 37.8 1.1 12 30.4 0.6 30
910 O 36.4 0.6 13 37.5 1.2 10
963 O 31 1 10 33.1 0.9 4
B6CBAT6F1 Females
30 Y 15.8 0.3 24
60 Y 18.4 0.2 12 18.9 0.3 12
90 Y 20.9 0.4 12 22.7 0.5 12 24.7 0.5 24
164 Y 24.3 0.5 12 25.5 0.7 12
210 Y 25.3 0.6 12 28.4 0.7 12 27.2 0.5 24
860 O 39.1 1 16 35.3 1.7 12 34.2 0.7 34
910 O 38.9 1.4 13 34.6 1.1 11
963 O 34.6 2 8 29.9 1.3 9
*- Young groups were fed activated lipid for 225 days and old groups were fed until death (at least 225 days)
The colony control is a larger group of mice which were weighed over several year and were treated similarly.


Figure VI.6. B6CBAT6F1 females: life span curves for activated lipid fed and control mice.

B6CBAT6F1 females: life span curves



Figure VI.7. Young mice (30 to 210 days): weight comparisons among lipid fed, control, and colony control mice.

Young mice: weight comparisons



Figure VI.8. Old mice (860 to 963 days): weight comparisons among lipid fed, control, and colony control mice.

Old mice: weight comparisons



Table VI.10. Biomarker values for young and old treated mice compared to controls.

Young (129 DAYS) Old (927 DAYS)
Activated Lipid Controls Activated Lipid Controls
TEST MEAN SE N MEAN SE N MEAN SE N MEAN SE N
PS 123 4.5 12 118 4.8 12 104 3.5 12 112 6.4 11
TW 186 21 12 156 24 12 24 5 12 33 11 10
OF 124 10 12 128 9.3 12 87.1 6.8 12 89.8 6.9 10
BOLI 1.1 0.4 12 0.3 0.3 12 0.8 0.3 12 0.5 0.4 10
BW 27.6 0.4 12 28.1 0.3 12 36.4 0.6 12 37.5 1.2 10
TL 9.3 0.05 12 9.7 0.03 11 10.2 0.04 12 10.5 0.03 9
HR 94.7 3.2 12 63.6 10 12 28 6.3 12 27 8.2 7
HCT 51.4 0.6 12 51.7 0.3 12 37.5 0.8 12 37.7 1.4 9
HB 16.4 0.6 12 16.4 0.07 12 11.8 0.4 12 12 0.5 9
TTC 8.6 0.7 12 9.5 0.7 12 171 15 13 188.3 18 6
WH 16 1.9 12 18.9 2.7 12 29.4 3.9 12 42.5 7.2 4
LS 982 12 14 962 13.4 11
Systems assayed: 

Behavioral: PS=paw strength; TW=tight wire; OF=open field; BOLI=fecal boli deposited during test.

Physiological: BW=body weight; TL=tail length; HR=hair regrowth rate; HCT=hematocrit; HB=hemoglobin; TTC=tail collagen denaturation rate; WH=wound healing rate; LS=life span. 

 

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Site last updated September 13, 2008.