Neuroprotection

We are interested in mechanisms of neuroprotection that may shield RGCs from glaucoma. Importantly, we have discovered a profound neuroprotective effect of a radiation and bone marrow treatment. The protective effect is long-lasting and prevents glaucoma in almost all treated mice. The magnitude of the protection is unprecedented and we are eager to understand the underlying biology, which may involve stem cells, trophic factors, neuronal-glial interactions or simply neuronal mechanisms. Experiments are underway to understand this neuroprotection. Additionally, we are testing the ability of focal ocular irradiation to prevent glaucoma.

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