Research Interests
We use genetics, genomics, cell biology and physiology to understand the fundamental biologic processes that cause disease, with a focus on neurodegeneration and glaucoma. Our work spans developmental biology, melanosomal biology, immunology, and neurobiology. In addition to glaucoma, we study stroke and age-related macular degeneration-relevant phenotypes. The following summary focuses on our glaucoma research.
Glaucoma affects 70 million people worldwide. In glaucoma, retinal ganglion cell death and optic nerve degeneration lead to blindness. Harmfully high intraocular pressure (IOP) is an important contributing factor in many cases. The genetic factors determining IOP and susceptibility to pressure-induced damage are largely unknown.
Research Areas
Intraocular Pressure
Pressure-Induced Damage in Glaucoma
Neuroprotection
Developmental Glaucoma
