Publications
After fellowships at the Armed Forces Institute of Pathology and two years as a research associate at the National Institutes of Health, Dr Smith joined the fulltime staff of the Ophthalmology Department at Albany Medical College and Albany Medical Center Hospital in upstate New York. He served for 10 years as Chairperson of the Department of Ophthalmology with a joint appointment in the Pathology Department. Dr. Smith came to JAX first as a visiting scientist in 1990, after a long career as a clinical ophthalmologist and ophthalmic pathologist. He joined the scientific staff in 1993 as a research scientist. He has worked closely with Dr John since 1995, and formally joined the John laboratory in 1998. Dr. Smith was the first to recognize the presence of glaucoma in aging DBA/2 mice. His skills in clinical examination and ophthalmic pathology and anatomy are the focus of his work in the John Lab. His skills and experience are invaluable for many projects, and are an important resource for training other lab members.
Howell GR, Libby RT, Jakobs TC, Phalan FC, Barter JW, Barbay JM, Smith RS, Wihtmore AV, Masland RH, John SWM. Submitted. Axons of retinal ganglion cells are insulted in the lamina early in a mouse glaucoma.
Brooks BP, Larson DM, Chan C-C, Kjellstrom S, Smith RS, Crawford MA, Lamoreus L, Huizing M, Hess R, Jiao X, Hejtmancik FJ, Maminishkis A, John SWM, Bush R, Pavan. 2007. Analysis of ocular hypopigmentation in Rab38cht/cht mice. Invest Ophthalmol Vis Sci In Press
Howell GR, Libby RT, Marchant JK, Wilson LA, Cosma IM, Smith RS, Anderson MG, John SWM. 2007. Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1. BMC Genet 8:45
Gould DB, Reedy M, Wilson LA, Smith RS, Johnson RL, John SWM. 2006. Mutant myocilin non-secretion in vivo is not sufficient to cause glaucoma. Mol Cell Biol 26: 8427-8436
Anderson MG, Libby RT, Mao M, Cosma IM, Wilson LA, Smith RS, John SWM. 2006. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol 4:20 http://www.biomedcentral.com/content/pdf/1741-7007-4-20.pdf
Libby RT, Anderson MG, Pang I-H, Robinson Z, Savinova OV, Cosma IM, Snow A, Wilson LA, Smith RS, Clark AF, John SWM. 2005. Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration. Vis Neurosci 22: 637-648
Libby RT, Yan L, Savinova OV, Barter J, Smith RS, Nickells RW, John SWM. 2005. Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet 1: 17-26 http://genetics.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pgen.0010004
Gould DB, Phalan FC, Breedveld GJ, van Mil SE, Smith RS, Schimenti JC, Aguglia U, van der Knaap MS, Heutink P, John SWM. 2005. Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly. Science 308: 1167-1171
Anderson MG, Libby RT, Gould DB, Smith RS, John SWM. 2005. High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma. Proc Natl Acad Sci USA 102: 4566-4571 http://www.pnas.org/cgi/content/full/102/12/4566
Link BA, Gray MP, Smith RS, John SWM. 2004. Intraocular pressure in zebrafish: comparison of inbred strains and identification of a reduced melanin mutant with raised IOP. Invest Ophthalmol Vis Sci 45: 4415-4422
Gould DB, Miceli-Libby L, Savinova OV, Torrado M, Tomarev SI, Smith RS, John SWM. 2004. Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma. Mol Cell Biol 24:9019-9025
Mo JS, Anderson MG, Gregory M, Smith RS, Savinova OV, Serreze DV, Ksander BR, Streilein JW, John SWM. 2003. By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma. J Exp Med 197: 1335-1344
Lehmann OJ, Tuft S, Brice G, Smith RS, Blixt A, Bell R, Jordan T, Hitchings RA, Khaw PT, John SWM, Carlsson P, Bhattacharya SS. 2003. Novel anterior segment phenotypes resulting from forkhead gene alterations: evidence for cross-species conservation of function. Invest Ophthalmol Vis Sci 44: 2627-2633
Libby RT, Smith RS, Savinova OV, Zabaleta A, Martin JE, Gonzalez FJ, John SWM. 2003. Modification of ocular defects in mouse developmental glaucoma models by tyrosinase. Science 299: 1578-1581 http://www.sciencemag.org/cgi/content/full/299/5612/1578?ijkey=RnOYI2djaEVuI&keytype=ref&siteid=sci
Smith RS, Korb D, John SWM. 2002. A goniolens for clinical monitoring of the mouse iridocorneal angle and optic nerve. Mol Vis 8: 26-31 http://www.molvis.org/molvis/v8a4/
Anderson MG, Smith RS, Hawes NL, Zabaleta A, Chang B, Wiggs JL, John SWM. 2002. Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat Genet 30: 81-85
Kim BS, Savinova OV, Reedy MV, Martin J, Lun Y, Gan L, Smith RS, Tomarev SI, John SWM, Johnson RL. 2001. Targeted disruption of myocilin (Myoc) suggests that human glaucoma-causing mutations are gain of function. Mol Cell Biol 21: 7707-7713
Chen Z, Karaplis AC, Ackerman SL, Pogribny IP, Melnyk S, Lussier-Cacan S, Chen MF, Pai A, John SWM, Smith RS, Bottiglieri T, Bagley P, Selhub J, Rudnicki MA, James, SJ, Rozen R. 2001. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Hum Mol Genet 10: 433-443
Smith RS, Zabaleta A, Savinova OV, John SWM. 2001. The mouse anterior chamber angle and trabecular meshwork develop without cell death. BMC Dev Biol 1: 3 http://www.biomedcentral.com/1471-213X/1/3
Chang B, Smith RS, Peters M, Savinova OV, Hawes NL, Zabaleta A, Nusinowitz S, Martin JE, Davisson MT, Cepko CL, Hogan BLM, John SWM. 2001. Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. BMC Genetics 2:18 http://www.biomedcentral.com/1471-2156/2/18
Savinova OV, Sugiyama F, Martin JE, Tomarev SI, Paigen BJ, Smith RS, John SWM. 2001. Intraocular pressure in genetically distinct mice: an update and strain survey. BMC Genetics 2:12 http://www.biomedcentral.com/1471-2156/2/12
Anderson MG, Smith RS, Savinova OV, Hawes NL, Chang B, Zabaleta A, Wilpan R, Heckenlively JR, Davisson MT, John SWM. 2001. Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice. BMC Genetics 2: 1 http://www.biomedcentral.com/1471-2156/2/1
Smith RS, Zabaleta A, Kume T, Savinova OV, Kidson SH, Martin JE, Nishimura DY, Alward WL, Hogan BLM, John SWM. 2000. Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. Hum Mol Genet 9: 1021-1032
Munroe RJ, Bergstron RA, Zheng QY, Libby B, Smith RS, John SWM, Schimenti KJ, Browning VL, Schimenti JC. 2000. Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet 24: 318-321
Smith RS, John SWM, Zabaleta A, Davisson MT, Hawes NL, Chang B. 2000. The Bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization. Proc Natl Acad Sci USA 97: 2191-2195
Hawes NL, Smith RS, Chang B, Davisson MT, Heckenlively JR, John SWM. 1999. Mouse fundus photography and angiography: A catalogue of normal and mutant phenotypes. Mol. Vis 5: 22-29.
Chang B, Smith RS, Hawes NL, Anderson MG, Zabaleta A, Savinova O, Roderick TH, Heckenlively JR, Davisson MT, John SWM. 1999. Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet 21: 405-409
John SWM, Smith RS, Hawes NL, Savinova OV, Chang B, Turnbull D, Davisson MT, Roderick TH, Heckenlively JR. 1998. Essential Iris atrophy, pigment dispersion and glaucoma in DBA2/J mice. Invest Ophthalmol Vis Sci 39: 951-962
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