Overview
There is an old saying that "pathology is the mother of medicine." Diseases, and more specifically the discipline of studying diseases (pathology), are why we have medicine and biomedical research. Correctly identifying a disease and the various processes each disease undergoes as it develops is the basis of most work done at The Jackson Laboratory. Through a collaborative effort of scientists in our Jackson Aging Center, we are identifying strain specific diseases in 32 heavily used inbred strains of mice and using modern genetic technologies are mapping the genes responsible for many of these diseases. As humans get similar diseases as they age, this information will be vitally important to studying complex genetic diseases associated with aging.
Alopecia areata, an autoimmune disease featuring hair loss, is a long-term focus of our laboratory group. We have identified four regions of the mouse genome that contain susceptibility genes for alopecia areata and have identified a critical gene in the primary effector cells. We are also characterizing how drug targets change during the development and progression of the disease and are working to make new diagnostic and prognostic tools available to the medical community. We also work on projects investigating chronic proliferative dermatitis and B6 alopecia as well as characterizing mutant mice with hair medulla defects and a new spontaneous mutant with blistering of the skin.
Scientific report
Experimental Dermatology and General Mouse Pathology
Our laboratory's primary interest is the identification and characterization of skin and adnexal diseases in laboratory mice as models for genetically based human skin diseases. However, since our group includes veterinarian and physician scientists, all with broad medical training, we are involved with identifying and defining mouse models for many different types of diseases including inflammatory bowel disease, autoimmune diseases, vascular and lymphatic abnormalities, and many other diseases affecting a variety of organ systems. Our horizons broadened even further when we became a critical part of the new Jackson Aging Center at The Jackson Laboratory.
Alopecia areata is a long-term major focus of our laboratory group. Alopecia areata and its more severe forms, alopecia totalis and universalis, are forms of a cell-mediated autoimmune skin disease that targets actively growing (anagen stage) hair follicles. Building on previous work done with Dr. Lloyd King (Vanderbilt U.) and several Jackson Laboratory Staff Scientists (Drs. Gregory Cox, Gary Churchill, and Renhua Li) in which we identified four quantitative trait loci (QTL) for our C3H/HeJ mouse model of alopecia areata, we used the haplotype in silico mapping approach, with the help of Benjamin King (The Jackson Laboratory), to identify a critical gene in the activation of CD8+ T cells, the primary effector cell. These findings are being confirmed in collaboration with immunologist Dr. Derry Roopenian (The Jackson Laboratory Staff Scientist and Bar Harbor Biotechnology). With funding from the National Alopecia Areata Foundation (NAAF), we set up a preclinical screening system for novel drug efficacy trials at the JAX West facility in West Sacramento, Calif., initially working with Dr. Kara Koehler and now with Dr. Leon Hall. To support this drug screening system, as well as to investigate the fundamental mechanisms involved in onset and progression of alopecia areata, we performed large-scale longitudinal gene expression analysis of our skin graft-induced C3H/HeJ mouse model using the Ingenuity Network Analysis program to identify known drug targets. This is part of Dr. Jing Sun's (The Jackson Laboratory) Ph.D. thesis project. Our results clearly confirmed that drug targets change throughout the development and progression of alopecia areata, indicating that effective treatment requires that specific drugs be used alone or in combination at various stages of the disease. These results help explain the frustration of patients with current treatment options. More importantly, we are identifying a variety of important molecular networks involved in the pathogenesis of alopecia areata. Our findings will help us create alopecia areata-specific molecular assays to provide physicians with more accurate diagnostic and prognostic tools. We are working closely with Dr. Derry Roopenian to develop and make these new tools available to the medical community.
Rosemarie Seymour, D.V.M., a veterinarian working on a Ph.D. through collaboration with the University of Maine in Orono, is studying the genetics and immunologic defects of the chronic proliferative dermatitis mutant mouse (cpdm). These mice develop severe alopecia and scaling due to large numbers of eosinophils in the dermis. Working with Dr. Harm HogenEsch (Purdue U.), we are investigating the cytokine and chemokine pathways in this disease. Previously we found that mutant mice fail to develop Peyer's patches in the intestine and that the secondary lymphoid tissues do not develop properly. Dr. Seymour's work focuses on the pathways involved in normal development of these structures and how this relates to the severe skin and overall systemic effects of this single-gene defect. Dr. Seymour recently identified the mutated gene in the cpdm mouse, and we are currently creating floxed alleles as well as yellow fluorescent protein-expressing transgenic mice to define the biological function of this novel gene in several organs. Drs. Gregory Cox and Leonard Shultz (The Jackson Laboratory) are active partners in this project.
We are also investigating the relatively common forms of hair loss and skin ulcers that arise spontaneously in C57BL/6 (B6) substrains of mice. This disease process is commonly referred to as B6 alopecia, chronic ulcerative dermatitis, or B6 dermatitis, and the severe form results from a primary hair follicle dystrophy. Working with Drs. Helen Everts, David Ong, and Lloyd E. King (all of Vanderbilt U.), we are focusing on abnormal vitamin A metabolism as an underlying mechanism in this disease. Comparative work with Drs. King and Leonard Sperling (Uniformed Services U.) indicates that this may be a new and much needed preclinical model for a form of human cicatrical alopecia.
Dr. Alexander Awgulewitsch (Medical U. South Carolina), an expert in homeobox gene regulation of hair follicle function, approached us to help his group characterize mutant mice with hair medulla defects resulting from overexpression or lack of expression of Hoxc13. Among the genes Hoxc13 interacts with is Foxq1, the gene mutated in satin mice, which also have a hair medulla abnormality. Dr. Baojin Wu, a visiting investigator here for a year from the Medical School of Yangzhou U., Yangzhou Jiangsu, China, recently identified the mutation in a new allelic mutation of satin (MRL/LpJ-Foxq1sa-J). He also recently identified the mutated gene responsible for the spontaneous mutation called hair interior defect (hid), which also has a hair medulla defect. All AKR/J mice are homozygous for this autosomal recessive mutation. Hid is located in an interval with no known genes involved in hair follicle development. We have narrowed our list of candidate genes and these are currently being sequenced. These results are part of a larger project with Dr. Awgulewitsch and his graduate students, Christopher Potter and Nathan Pruett (Medical U. South Carolina), to use hair medulla formation as a paradigm for analyzing gene networks involved in hair follicle differentiation. We have an expanding group of novel and historical mutant strains and stocks with hair medulla defects that involve many different autosomal recessive mutations. These unique tools are critical to define the gene networks involved in normal and abnormal skin and hair biology.
Working with Drs. Derry Roopenian and Jason Bubier (The Jackson Laboratory) we discovered a new spontaneous mutant mouse that results in blistering of the skin, particularly around the ears. It was initially named sore ears for this reason. Abnormalities in the basement membrane indicate that this is a form of junctional epidermolysis bullosa. We are doing comparative studies with Drs. Joe-David Fine and Lloyd E. King, Jr. (Vanderbilt U.). We recently identified the mutated gene and are using the model to identify modifier genes that affect quality and length of life.
Our laboratory provides the pathology infrastructure for the Jackson Aging Center. All mice utilized in this project are brought to us for detailed physiologic and pathologic phenotyping, which includes designing and coordinating numerous ancillary studies with scientists in-house and around the world. We coordinate our work with Drs. David Harrison and Beverly Paigen (The Jackson Laboratory). Histopathology results and disease frequency are posted on the Mouse Phenome Database and Mouse Tumor Biology Database (with Drs. Janan Eppig and Dale Begley, The Jackson Laboratory). These data are also included in Pathbase (with Dr. Paul Schofield, Cambridge U., Cambridge, UK), a mouse pathology database that integrates the expertise of many mouse pathologists to make public annotated images of all diseases in laboratory mice. These data will be part of a large-scale haplotype mapping project to identify genes responsible for chronic debilitating spontaneous diseases. We are also collaborating with Dr. Paul Schofield (Cambridge U.) and Beth Sundberg (The Jackson Laboratory) to expand Pathbase by developing a subdirectory, Skinbase, that describes mutant mice with skin, hair, and nail abnormalities, including information on normal anatomic structures, coordinated with the assistance of a medical specialist to use terms familiar to both veterinarians and physicians.
Training programs for veterinarians and physicians interested in mouse research and pathology continue both here at The Jackson Laboratory as well as off campus. Dr. Thomas Chase, working in Dr. Leonard Shultz's laboratory, is currently on our NIH T32 training grant for veterinarians. Dr. Seymour (see above) completed her work on the T32 training grant and was awarded an NIH K08 Mentored Clinical Scientist grant. Our annual week-long training course for pathologists (Pathology of Mouse Models for Human Diseases) was held this year at the Fred Hutchinson Cancer Center in Seattle and will be held at The Jackson Laboratory in September 2007. Dr. Sundberg conducted a series of minicourses on mouse pathology and mouse databases at Northwestern U., Purdue U., the University of Illinois, and many others are being planned.
Lab staff
Principal Investigator: John P. Sundberg, D.V.M., Ph.D., Diplomate, A.C.V.P.
Research Assistant III: Kathleen Silva
Laboratory Technician IV: Vicki Kennedy
Software Engineer I: Beth A. Sundberg, B.A., M.S.
Postdoctoral Fellow: Christopher Potter, D.V.M.
Visiting Investigators: André Bleich, D.V.M., Ph.D., Institut für Versuchstierkunde und Zentrales Tierlaboratorium der Medizinischen Hochschule Hannover, Hannover, Germany, Helen Everts, Ph.D., Department of Biochemistry, Vanderbilt University Medical Center, Nashville, Tenn., Robert Hackman, M.D., Departments of Pathology and Laboratory Medicine, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Wash., Harm HogenEsch, D.V.M., Ph.D., Dipl. A.C.V.P., Department of Veterinary Pathobiology, Purdue University, West Lafayette, Ind., Herbert C. Morse III, M.D., Chief, Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Md., Paul N. Schofield, Ph.D., Department of Anatomy, University of Cambridge, Cambridge, U.K., Douglas Taylor, D.V.M., Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Mich., Yun You, Ph.D., Mammalian Genetics and Genomics Group, Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tenn.
Research Administrative Assistant: Norma D. Buckley
Publication listings
2012
Wang Z, Potter CS, Sundberg JP, Hogenesch H. 2012. SHARPIN is a key regulator of immune and inflammatory responses. J Cell Mol Med, in press
Sundberg JP, Hogenesch H, Nikitin AY, Treuting PM, Ward JM. 2012. Training mouse pathologists: Ten years of workshops on the pathology of mouse models of human disease. Toxicol Pathol, in press
Sproule TJ, Roopenian DC, Sundberg JP. 2012. A direct method to determine the strength of the dermal-epidermal junction in a mouse model for epidermolysis bullosa. Exp Dermatol, in press
Sundberg JP, Ward JM, Hogenesch H, Nikitin AY, Treuting PM, Macauley JB, Schofield PN. 2012. Training pathologists in mouse pathology. Vet Pathol 49: 393-397. PMCID: PMC3329931
McPhee CG, Duncan FJ, Silva KA, King LE Jr, Hogenesch H, Roopenian DC, Everts HB, Sundberg JP. 2012. Increased expression of Cxcr3 and its Ligands, Cxcl9 and Cxcl10, during the development of Alopecia Areata in the mouse. J Invest Dermatol, in press
Schofield PN, Vogel P, Gkoutos GV, Sundberg JP. 2012. Exploring the elphant: histopathology in high-throughput phenotyping of mutant mice. Dis Model Mech 5: 19-25. PMCID: PMC3255539
Alli R, Nguyen P, Boyd K, Sundberg JP, Geiger TL. 2012. A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. J Immunol 188: 477-486. PMCID: PMC3244525
Wang Z, Sokolovska A, Seymour R, Sundberg JP, Hogenesch H. 2012. SHARPIN is essential for cytokine production, NF-kB signaling, and induction of Th1 differentiation by dendritic cells. PLoS One 7: e31809. PMCID: PMC3279418
Taylor DK, Bubier JA, Silva KA, Sundberg JP. 2012. Development, structure, and keratin expression in C57BL/6J mouse eccrine glands. Vet Pathol 49: 146-154. PMCID: PMC3253413
Sundberg JP, Silva KA. 2012. What color is the skin of a mouse. Vet Pathol 49: 142-145
Kavirayani AM, Sundberg JP, Foreman O. 2012. Primary neoplasms of bones in mice: retrospective study and review of literature. Vet Pathol 49: 182-205. PMCID: PMC3151475
Begley DA, Krupke DM, Neuhauser SB, Richardson JE, Bult CJ, Eppig JT, Sundberg JP. 2012. The mouse tumor biology database (MTB):: A central electronic resource for locating and integrating mouse tumor pathology data. Vet Pathol 49: 218-223. PMCID: PMC3130112
2011
Liang Y, Silva KA, Kennedy V, Sundberg JP. 2011. Comparisons of mouse models for hair follicle reconstitution. Exp Dermatol 20: 1011-1015
Sundberg JP, McElwee KJ, Carroll JM, King LE Jr. 2011. Hypothesis testing: CTLA4 co-stimulatory pathways critical in the pathogenesis of human and mouse alopecia areata. J Invest Dermatol 131: 2323-2324. Letter
Rantala JK, Pouwels J, Pellinen T, Veltel S, Laasola P, Mattila E, Potter CS, Duffy T, Sundberg JP, Kalloniemi O, Askari JA, Humphries MJ, Parsons M, Salmi M, Ivaska J. 2011. SHARPIN is an endogenous inhibitor of B1-integrin activation. Nat Cell Biol 13: 1315-1324. PMCID: PMC3257806
Schofield PN, Sundberg JP, Hoehndorf R, Gkoutos GV. 2011. New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models. Brief Funct Genomics 10: 258-265. PMCID: PMC3189694
Berndt A, Cario CL, Silva KA, Kennedy VE, Harrison DE, Paigen B, Sundberg JP. 2011. Identification of Fat4 and Tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas. Cancer Res 71: 5779-5791. PMCID: PMC3165088
Liang Y, Sundberg JP. 2011. SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes. J Dermatol Sci 63: 148-153. PMCID: PMC3152647
Rice RH, Phillips MA, Sundberg JP. 2011. Localization of hair shaft protein VSIG8 in the hair follicle, nail unit, and oral cavity. J Invest Dermatol 131: 1936-1938. PMCID: PMC3156960
Webb CM, Cameron EM, Sundberg JP. 2011. Fluorescence-labeled reporter gene in transgenic mice provides a useful tool for investigating cutaneous innervation. Vet Pathol, in press. PMCID: PMC3323669
Sundberg JP, Rozell B, Everts H. 2011. Association between hair-induced oronasal inflammation and ulcerative dermatitis in C57BL/6 mice. Comp Med 61: 204-205. PMCID: PMC3123751
Potter CS, Pruett ND, Kern MJ, Baybo MA, Godwin AR, Potter KA, Peterson RL, Sundberg JP, Awgulewitsch A. 2011. The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation. J Invest Dermatol 131: 828-837. PMCID: PMC3059342
Schofield PN, Dubus P, Klein L, Moore M, McKerlie C, Ward JM, Sundberg JP. 2011. Pathology of the laboratory mouse: an international workshop on challenges for high throughput phenotyping. Toxicol Pathol 39: 559-562
Ikeda F, Deribe YL, Skanland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I. 2011. SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. Nature 471: 637-641. PMCID: PMC3085511
Bolon B, Altrock B, Barthold SW, Baumgarth N, Besselsen D, Boivin G, Boyd KL, Brayton C, Cardiff RD, Couto S, Eaton KA, Foreman O, Griffey SM, La Perle K, Lairmore MD, Liu C, Meyerholz DK, Nikitin AY, Schoeb TR, Schwahn D, Sellers RS, Sundberg JP, Tolwani R, Valli VE, Zink MC. 2011. Advancing translational research. Science 331: 1516-1517
Joh J, Jenson AB, King W, Proctor M, Ingle A, Sundberg JP, Ghim SJ. 2011. Genomic analysis of the first laboratory-mouse papillomavirus. J Gen Virol 92: 692-698
Sundberg JP, Taylor D, Lorch G, Miller J, Silva KA, Sundberg BA, Roopenian D, Sperling L, Ong D, King LE, Everts H. 2011. Primary follicular dystrophy with scarring dermatitis in C57BL/6 mouse substrains resembles central centrifugal cicatricial alopecia in humans. Vet Pathol 48: 513-524. PMCID: PMC3101716
Ingle A, Ghim S, Joh J, Chepkoech I, Bennett Jenson A, Sundberg JP. 2011. Novel laboratory mouse papillomavirus (MusPV) infection. Vet Pathol 48: 500-505
Liang Y, Seymour RE, Sundberg JP. 2011. Inhibition of NF-kappaB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice. J Invest Dermatol 131: 141-149. PMCID: PMC3071979
Sher RB, Cox GA, Mills KD, Sundberg JP. 2011. Rhabdomyosarcomas in aging A/J mice. PLoS One 6: e23498. PMCID: PMC3154500
Sundberg JP, Blake J, Szauter P, Ward JM. 2011. Mouse pathology books online. Vet Pathol 48: 730
2010
Wu B, Potter CS, Silva KA, Liang Y, Reinholdt LG, Alley LM, Rowe LB, Roopenian DC. Awgulewitsch A, Sundberg JP. 2010. Mutations in Sterol O-Acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice. J Invest Dermatol 130: 2666-2668. PMCID: PMC2955156
Sundberg JP, Schofield PN. 2010. Commentary: mouse genetic nomenclature. Standardization of strain, gene, and protein symbols. Vet Pathol 47: 1100-1104. PMCID: PMC3039125
Schofield PN, Gruenberger M, Sundberg JP. 2010. Pathbase and the MPATH ontology: Community resources for mouse histopathology. Vet Pathol 47: 1016-1020. PMCID: PMC3038412
Sundberg JP, Ward JM, Hogenesch H, Nikitin AY, Treuting PM, Macauley JB, Schofield PN. 2010. Training Pathologists in mouse pathology. Vet Pathol
Fluhr JW, Elias PM, Man MQ, Hupe M, Selden C, Sundberg JP, Tschachler , Eckhart L, Mauro TM, Feingold KR. 2010. Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification? J Invest Dermatol 130: 2141-2144
Bubier JA, Sproule TJ, Alley LM, Webb CM, Fine JD, Roopenian DC, Sundberg JP. 2010. A mouse model of generalized non-herlitz junctional epidemolysis bullosa. J Invest Dermatol 130: 1819-1828. PMCID: PMC3010368
Bolon B, Barthold SW, Boyd KL, Brayton C, Cardiff RD, Cork LC, Eaton KA, Schoeb TR, Sundberg JP, Ward JM. 2010. Male mice not alone in research. Science 328: 1103
Schofield PN, Gkoutos GV, Gruenberger M, Sundberg JP, Hancock JM. 2010. Phenotype ontologies for mouse and man: bridging the semantic gap. Dis Model Mech 3: 281-289. PMCID: PMC2860848
Bleich A, Buchler G, Beckwith J, Petell LM, Affourtit JP, King BL, Shaffer DJ, Roopenian DC, Hedrich HJ, Sundberg JP, Leiter EH. 2010. Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity. Inflamm Bowel Dis 16: 765-775. PMCID: PMC2857671
Jurisic G, Sundberg JP, Bleich A, Leiter EH, Broman KW, Buechler G, Alley L, Vestweber D, Detmar M. 2010. Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease. Genes Immun 11: 219-231. PMCID: PMC2865135
Odgren PR, Pratt CH, Mackay CA, Mason-Savas A, Curtain M, Shopland L, Ichicki T, Sundberg JP, Donahue LR. 2010. Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathies. PLoS One 5: e9959. PMCID: PMC2848607
Renninger ML, Seymour RE, Whiteley LO, Sundberg JP, Hogenesch H. 2010. Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in Sharpin-deficient mice. Exp Dermatol 19: 252-258. PMCID: PMC2852468
Sundberg JP, Silva KA, McPhee C, King LE, Jr. 2010. Skin diseases in laboratory mice: approaches to drug target identification and efficacy screening. Methods Mol Biol 602: 193-213
Liu Y, Sundberg JP, Das S, Carpenter D, Cain KT, Michaud EJ, Voy BH. 2010. Molecular basis for hair loss in mice carrying a novel nonsense mutation (Hrrh-R) in the hairless gene (Hr). Vet Pathol 47: 167-176. PMCID: PMC2865226
2009
Sundberg BA, Schofield PN, Gruenberger M, Sundberg JP. 2009. A data-capture tool for mouse pathology phenotyping. Vet Pathol 46: 1230-1240. PMCID: PMC2879151
Sundberg JP, Ward JM, Schofield P. 2009. Where's the mouse info? Vet Pathol 46: 1241-1244
Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM. 2009. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol 124: 496-506. PMCID: PMC2881668
Rice RH, Rocke DM, Tsai HS, Silva KA, lee YJ, Sundberg JP. 2009. Distinguishing mouse strains by proteomic analysis of pelage hair. J Invest Dermatol 129: 2120-2125. PMCID: PMC2853740
Sundberg JP, Schofield PN. 2009. A mouse by any other name. J Invest Dermatol 129: 1599-1601
Sundberg JP, Schofield PN. 2009. One medicine, one pathology, and the one health concept. J Am Vet Med Assoc 234: 1530-1531
Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B. 2009. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 8: 277-287. PMCID: PMC2768517
Giehl KA, Potter CS, Wu B, Silva KA, Rowe LB, Awgulewitsch A, Sundberg JP. 2009. Hair interior defect in AKR/J mice. Clin Exp Dermatol 34: 509-517. PMCID: PMC2868196
Fallon PG, Sasaki T, Sandilands A, Campbell LE, Saunders SP, Mangan NE, Callanan JJ, Kawasaki H, Shiohama A, Kubo A, Sundberg JP, Presland RB, Fleckman P, Shimizu N, Kudoh J, Irvine AD, Amagai M, McLean WH. 2009. A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet 41: 602-608. PMCID: PMC2872154
Joh J, Hopper K, Van Doorslaer K, Sundberg JP, Jenson AB, Ghim SJ. 2009. Macaca fascicularis papillomavirus type 1: a non-human primate betapapillomavirus causing rapidly progressive hand and foot papillomatosis. J Gen Virol 90(Pt 4): 987-994
Sundberg JP, Silva KA, Zhang W, Sundberg BA, Edwards K, King LE, Davis RL, Black S. 2009. Recombinant human hepatitis B vaccine initiating alopecia areata: testing the hypothesis using the C3H/HeJ mouse model. Vet Dermatol 20: 99-104. PMCID: PMC2956183
Schofield PN, Brown SD, Sundberg JP, Arends M, Warren MV, Dubus P, Ellender M, Fiette L, Rozell B, Quintanilla-Martinez L, Raspa M, Song JY, van der Valk M, McKerlie C. 2009. PRIME importance of pathology expertise. Nat Biotechnol 27: 24-25
2008
Mentzer SE, Sundberg JP, Awgulewitsch A, Chao HH, Carpenter DA, Zhang WD, Rinchik EM, You Y. 2008. The mouse hairy ears mutation exhibits an extended growth (anagen) phase in hair follicles and altered Hoxc gene expression in the ears. Vet Dermatol. 19: 358-367. PMCID: PMC3061202
Fantauzzo KA, Tadin-Strapps M, You Y, Mentzer SE, Baumeister FA, Cianfarani S, van Maldergem L, Warburton D, Sundberg JP, Christiano AM. 2008. A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice. Hum Mol Genet 17: 3539-3551. PMCID: PMC2572698
Sun J, Silva KA, McElwee KJ, King LE Jr, Sundberg JP. 2008. The C3H/HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results. Exp Dermatol. 17: 793-805. PMCID: PMC2778023
Ghim S, Jenson AB, Bubier JA, Silva KA, Smith RS, Sundberg JP. 2008. Cataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRTI-14. Exp Mol Pathol. 85: 77-82. PMCID: PMC2650106
Pruett ND, Visconti RP, Jacobs DF, Scholz D, McQuinn T, Sundberg JP, Awgulewitsch A. 2008. Evidence for Hox-specified positional identities in adult vasculature. BMC Dev Biol. 8: 93. PMCID: PMC2570687
Bleich A, Kirsch P, Sahly H, Fahey J, Smoczek A, Hedrich HJ, Sundberg JP. 2008. Klebsiella oxytoca: opportunistic infections in laboratory rodents. Lab Anim 42: 369-375
Rehg JE, Sundberg JP. 2008. Utility of anti-Pax5 in the diagnosis of lymphoproliferative disorders and neoplasia in mice. Comp Med. 58: 246-252. PMCID: PMC2704114
Sundberg JP, Sundberg BA, Scholfield P. 2008. Integrating mouse anatomy and pathology ontologies into a phenotyping database: Tools for data capture and training. Mamm Genome 19: 413-419. PMCID: PMC2844541
Krupke DM, Begley DA, Sundberg JP, Bult CJ, Eppig JT. 2008. The Mouse Tumor Biology database. Nat Res Cancer. 8: 459-465. PMCID: PMC2574871
Bleich A, Sundberg JP, Smoczek A, von Wasielewski R, de Buhr MF, Janus LM, Julga G, Ukena SN, Hedrich HJ, Gunzer F. 2008. Sensitivity to Escherichia coli Nissle 1917 in mice is dependent on environment and genetic background. Int J Exp Pathol 89: 45-54
Chen J, Jaeger K, Den Z, Koch PJ, Sundberg JP, Roop DR. 2008. Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita. J Invest Dermatol 128: 270-279
King LE, Jr., McElwee KJ, Sundberg JP. 2008. Alopecia areata. Curr Dir Autoimmun 10: 280-312
2007
Begley DA, Krupke DM, Vincent MJ, Sundberg JP, Bult CJ, Eppig JT. 2007. Mouse Tumor biology Database (MTB): status update and future directions. Nucleic Acids Res 35: D638-642. PMCID: PMC1751545
Barthold SW, Borowsky AD, Brayton C, Bronson R, Cardiff RD, Griffey SM, Ince TA, Nikitin AY, Sundberg JP, Valli VE, Ward JM. 2007. From whence will they come? - A perspective on the acute shortage of pathologists in biomedical research. J Vet Diagn Invest 19: 455-456
Everts HB, Sundberg JP, King LE, Jr., Ong DE. 2007. Immunologicalization of enzymes, binding proteins, and receptors sufficient for retinoic acid synthesis and signaling during the hair cycle. J Invest Dermatol 127: 1593-1604
Liu Y, Das S, Olszewski RE, Carpenter DA, Culiat CT, Sundberg JP, Soteropoulos P, Liu X, Doktycz MJ, Michaud EJ, Voy BH. 2007. The near-naked hairless (Hr(N)) mutation disrupts hair formation but is not due to a mutation in the Hairless coding region. J Invest Dermatol 127: 1605-1614
Rector A, Lemey P, Tachezy R, Mostmans S, ghim SJ, Van Doorslaer K, Roelke M, Bush M, Montali RJ, Joslin J, Burk RD, Jenson A, Sundberg JP, Shapiro B, Van Ranst M. 2007. Ancient papillomavirus-host co-speciation in Felidae. Genome Biol 8: R57. PMCID: PMC1896010
Seymour RE, Hasham MG, Cox GA, Shultz LD, Hogenesch H, Roopenian DC and Sundberg JP. 2007. Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immun. 8: 416-421
Siebenhaar F, Shrov AA, Peters EM, Sharova TY, Syska W, Mardaryev AN, Freyschmidt-Paul P, Sundberg JP, Maurer M, Botchkarev VA. 2007. Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata). J Invest Dermatol 127: 1489-1497
Stranges PB, Watson J, Cooper CJ, Choisy-Rossi CM, Stonebraker AC, Beighton RA, Hartig H, Sundberg JP, Servick S, Kaufmann G, Fink PJ and Chervonsky AV. 2007. Elimination of antigen-presenting cells and autoreactive T cells by fas contributes to prevention of autoimmunity. Immunity 26: 629-641. PMCID: PMC2575811
Sundberg JP, Hackman RC, HogenEsch H, Nikitin AY and Ward JM. 2007. Training mouse pathologists: five years of pathology of mouse models of human disease workshops. Toxicol Pathol 35: 447-448
Sundberg JP, Silva KA, Edwards K, Black S, Jenson AB, King LE. 2007. Failure to induce alopecia areata in C3H/HeJ mice with exogenous interferon gamma. J Exp Anim Sci 43: 265-270
van Doorslaer K, Rector A, Jenson AB, Sundberg JP, van Ranst M and Ghim SJ. 2007. Complete genomic characterization of a murine papillomavirus isolated from papillomatous lesions of a European harvest mouse (Micromys minutus). J Gen Virol 88: 1484-1488
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