Publications:
Hasham MG, Donghia NM, Coffey E, Maynard J, Snow KJ, Ames J, Wilpan RY, He Y, King BL, Mills KD. 2010. Widespread genomic breaks generated by activation induced cytidine deaminase are prevented by homologous recombination. Nat Immunol 11(9):820-826.
Snow KJ, Wright SM, Woo Y, Titus LC, Mills KD, Shopland LS. 2010. Nuclear positioning, higher-order folding, and gene expression of Mmu15 sequences are refractory to cromosomal translocation. Chromosoma (in press). Aug 12 [Epub ahead of print].
Ng SH, Maas SA, Petkov PM, Mills KD, Paigen K. 2009. Co-localization of somatic and meiotic double strand breaks near the Myc oncogene on mouse chromosome 15. Genes Chromosome Cancer 48(10):925-930.
Singh P, Alley TL, Wright SM, Kamdar S, Schott W, Wilpan RY, Mills KD, Graber JH. 2009. Global changes in processing of mRNA 3' untranslated regions characterize clinically distinct cancer subtypes. Cancer Res 69(24):9422-9430.
Wright SM, Woo YH, Alley TL, Shirley BJ, Akeson EC, Snow KJ, Maas SA, Elwell RL, Foreman O, Mills KD. 2009. Complex oncogenic translocation with gene amplification are initiated by specific DNA breaks in lymphocytes. Cancer Res 69(10):4454-460.
Yuan R, Tsaih SW, Petkova SB, Evsikova CM, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B. 2009. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 8:277-287.
Maas S, Caddle LB, Mills KD. 2008. Mechanisms of DNA double strand break repair in hematopoietic homeostasis and oncogenesis. In Mouse Model of Human Blood Cancers. Li S, Editor. Springer Press.
Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. 2008. SIRT1 redistribution on chromatin promotes genomic stabiliy but alters gene expression during aging. Cell 135:907-918.
Caddle LB, Hasham MG, Schott W, Shirley BJ, Mills KD. 2008 Homologous recombination is necessary for normal lymphocyte development. Mol Cell Biol (In Press).
Caddle LB, Grant JL, Szatkiewicz J, van Hase J, Shirley BJ, Bewersdorf J, Cremer C, Arneodo A, Khalil A, Mills KD. 2007. Chromosome neighborhood composition determines translocation outcomes after exposure to high-dose radiation in primary cells. Chromosome Res. 15:1061-1073.
Hess ST, Gould TJ, Gudheti MV, Maas SA, Mills KD, Zimmerberg J. 2007. Dynamic clustered distribution of hemagglutinin resolved at 40 nm in living cell membranes discriminates between raft theories. Proc Natl Acad Sci USA. 104:17370-17375.
Khalil A, Grant JL, Caddle LB, Atzema E, Mills KD, Arneodo A. 2007. Chromosome territories have a highly nonspherical morphology and nonrandom positioning. Chromosome Res. 15:899-916.
Woo Y, Wright SM, Maas SS, Alley TL, Caddle LB, Kamdar S, Affourtit J, Foreman O, Akeson EC, Shaffer D, Bronson RT, Morse 3rd, Roopenian D, Mills KD. 2007. The Nonhomologous end joining factor Artemis suppresses multi-tissue tumor formation and prevents loss of hetrozygosity. Oncogene 26:6010-6020.
Yan CT, Kaushal D, Murphy M. Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Rox E, Bronson R, De Girolami U, Lee C, Alt FW. 2006. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci USA. 103:7378-7383.
Morales JC, Franco S, Murphy MM, Bassing CH, Mills KD, Adams MM, Walsh NC, Manis JP, Rassidakis GZ, Alt FW, Carpenter PB. 2006. 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proc Natl Acad Sci USA. 103:3310-3315.
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW. 2006. Genomic instability and aging-like phenotype in the absence os mammalian SIRT6. Cell 124:315-329.
Couedel C, Mills KD, Marco B, Shen L, Olshen A, Johnson RD, Nussenzweig A, Essers J, Kanaar R, Li GC, Alt FW, Jasin M. 2004. Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev 18:1293-1304.
Mills KD, Ferguson DO, Essers J, Eckersdorff M, Kanaar R, Alt FW. 2004. Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes Dev 18:1283-1292
Mills, K.D., Ferguson, D.O., and Alt, F.W. The Role of DNA Breaks in Genomic Instability and Tumorigenesis. (2003) Immunological Reviews 194: 77-95.
Zhu, C**., Mills, K.D.**., Ferguson, D.O**., Lee, C., Manis, J., Fleming, J., Gao, Y., Morton, C.C., and Alt., F.W. (2002). Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations. Cell 109: 811-821.
Mills, K. Silencing, Heterochromatin, and DNA Double Strand Break Repair in Saccharomyces cerevisiae. (2000) Kluwer Academic Publishers.
Mills, K.D.**., Sinclair, D.A**., and Guarente, L. (1999). MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell 97: 609-620.
Sinclair, D.A., Mills, K., and Guarente, L. (1998). Molecular mechanisms of yeast aging. Trends Biochem 23: 131-134.
Sinclair, D.A., Mills, K, and Guarente, L. (1998). Aging in Saccharomyces cerevisiae. Annu. Rev. Microbiol. 51: 134-162.
Sinclair, D.A., Mills, K., and Guarente, L. (1997). Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 mutants. Science 277: 1313-1316.
Kennedy, B.K., Gotta, M., Sinclair, D.A., Mills, K., McNabb, D.S., Murthy, M., Pak, S.M., Laroche, T., Gasser, S.M., and Guarente, L. (1997). Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89: 381-391
