Research Description:
DNA double strand breaks (DSB) are serious chromosomal lesions that can lead to cell death or neoplastic transformation. Mammalian cells possess sophisticated and intricate mechanisms to sense and repair DNA breaks, thus maintaining genomic integrity and ensuring faithful and efficient replication of genetic material. The research interest of our laboratory is to understand the mechanisms that maintain genome stability and how they relate to human pathology, broadly focusing on three main topics:
1. Basic Mechanisms of Genome Stability
2. Genome Instability in Tumorigenesis
3. Molecular and Genetic Pathobiology in a Mouse Model of B-ALL
