We are developing database tools for recording mouse pathology diagnoses/phenotypes. Our aim is to develop record keeping for necropsy results that uses a standardized ontology of terms and is also easy to use. MoDIS links to the Pathbase.net website to provide detailed information and annotated images of similar lesions in laboratory mice, making it a unique and useful training aid.
Please cite this page as: http://research.jax.org/faculty/sundberg/index.html
Current Version 3.6 (8/13/08)
Introduction: The Mouse Information System (MoDIS) is a database program written for Microsoft Access® and is used for storing and analyzing necropsy cases.
System requirement: Windows 2000 or XP. Microsoft Access 2003. Software is not tested on Windows Vista or Microsoft Access 2007.
Installation: The installation steps are described in the MoDIS Program Documentation. This software may be run stand-alone or in a multi-user environment with a client-server setup. Normal configuration requires the server and workstations to be using Windows. It is possible to use a Mac as a client workstation by employing application delivery software such as Citrix XenApp™, remote access via Microsoft's Remote Desktop Client for Mac, or Microsoft Virtual PC.
Manual: The user guide and program documentation is included with the download as Microsoft Word® 2003 documents.
Authors: MoDIS was developed by John P. Sundberg, D.V.M., Ph.D., Dipl. A.C.V.P., and Beth A. Sundberg, M.S., at The Jackson Laboratory in Bar Harbor, Maine USA.
Planned Future Developments: This database is being integrated into Pathbase with the European Mouse Pathology Consortium to expand to higher level ontologies. Data on all lesions identified in 32 inbred strains at 12 and 20 months of age are summarized in Pathbase, Mouse Tumor Biology, and Mouse Phenome databases with images and disease frequency, which provides several accessible resources to find online case materials for lesions with similar diagnoses in both inbred strains (spontaneous diseases) as well as many different genetically engineered mice. This is a constantly developing series of databases that provide resources for confirmation of diagnoses, information on other strains, stocks, and mutant mice with similar types of diseases, and opportunities for investigators and pathologists to report (provide images and data) their work online and solicit expert opinions from collaborating pathologists worldwide.
References: Sundberg BA, Sundberg JP. A database system for small diagnostic pathology laboratories. Lab Anim 19:55-58, 1990.
Sundberg BA, Sundberg JP. Medical record keeping for project analysis. In: Systematic approach to evaluation of mouse mutations. Sundberg JP, Boggess D (eds.), CRC Press, Inc., Boca Raton, FL, pp. 47-55, 2000.
Schofield PN, Bard JBL, Rozell B, Sundberg JP: Computational pathology: challenges in the informatics of phenotype description in mutant mice. In: Handbook on genetically engineered mice, eds. Sundberg JP, Ichiki T (ed.), pp. 61-81. CRC Press, Boca Raton, 2005
Krupke DM, Begley DA, Sundberg JP, Bult CJ, Eppig JT. The Mouse Tumor Biology database. Nature Rev Cancer Advance Online Publication 24 April 2008; doi:10.1038/nrc2390.
Bogue MA, Grubb SC, Maddatu TP, Bult CJ: Mouse Phenome Database (MPD). Nucleic Acids Res 35: D643-649, 2007
Sundberg JP, Sundberg BA, Schofield P. Integrating Mouse Anatomy and Pathology Ontologies into a Phenotyping Database: Tools for Data Capture and Training. Mam Genome (submitted)
Sundberg BA, Schofield PN, Sundberg JP. An open source database for mouse pathology phenotyping. Vet Pathol (submitted)
DOWNLOAD: In order to receive a copy of the current version of MoDIS and documentation please read and accept the following notice and fill out a simple registration form. After clicking "Register" you will be taken to the download page.
THE JACKSON LABORATORY MAKES NO REPRESENTATION ABOUT THE SUITABILITY OR ACCURACY OF THIS SOFTWARE FOR ANY PURPOSE, AND MAKES NO WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR THAT THE USE OF THIS SOFTWARE WILL NOT INFRINGE ANY THIRD PARTY PATENTS, COPYRIGHTS, TRADEMARKS, OR OTHER RIGHTS. THE SOFTWARE IS PROVIDED "AS IS". THE SOFTWARE IS PROVIDED TO ENHANCE KNOWLEDGE AND ENCOURAGE PROGRESS IN THE SCIENTIFIC COMMUNITY AND ARE TO BE USED ONLY FOR RESEARCH AND EDUCATIONAL PURPOSES. ANY REPRODUCTION OR USE FOR COMMERCIAL PURPOSE IS PROHIBITED WITHOUT THE PRIOR EXPRESS WRITTEN PERMISSION OF THE JACKSON LABORATORY. ALL RECIPIENTS OF THIS DOWNLOAD ARE RESPONSIBLE FOR OBTAINING THEIR OWN COPY OF THE MICROSOFT ACCESS ® PROGRAM.
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