Work with Genetic Resource Science
Our team collaborates with other scientists to facilitate research progress. The capacity of our breeding facilities, our mouse husbandry experience and our collective scientific expertise enable us to provide resource support to projects that require large numbers of mice or require access to strains of mice that are not broadly available. Our diverse experience and expertise allow us to approach research problems from broad perspectives.
Examples include:
-
Mouse Genomes Project: We have worked closely with the Sanger institute to provide essential biological resources for the Mouse Genomes Project. The project is using high throughput sequencing to sequence the genomes of 17 important inbred mouse strains and to provide a full picture of genomic variation among these strains. This work was recently published in Nature and all of the data are freely available through the Mouse Genomes Project website.
-
Friedreich's Ataxia: In a collaboration with a pharmaceutical company we are studying the induction of frataxin using HDAC inhibitors in Friedreich's ataxia mice. The purpose of this effort is to assess Friedreich's Ataxia models and their response to known inducers of frataxin as observed in human patient fibroblast cells.
-
Cardiac development: We are collaborating with an investigator at The University of Pittsburg on a saturation ENU-mutagenesis project to screen for genes involved in cardiac development. ENU-induced mutation strains with cardiac development anomalies will populate the "G1 male archive," which will include cryopreserved sperm, DNA and tissue from G1 males that have been shown to harbor mutations affecting cardiac development.
