Work with Genetic Resource Science
Our team collaborates with other scientists to facilitate research progress. The capacity of our breeding facilities, our mouse husbandry experience and our collective scientific expertise enable us to provide resource support to projects that require large numbers of mice or require access to strains of mice that are not broadly available. Our diverse experience and expertise allow us to approach research problems from broad perspectives.
- Knockout Mouse Project:
We are partners in an international effort to develop a full library of knockout mice and annotated gene information. As one of three KOMP2 centers, we are generating over 800 knockout strains, assuring the genetic quality, and evaluating the viability and fecundity of each.
Spinal Muscular Atrophy (SMA):
We are characterizing a novel set of SMA strains, designed by the SMA Foundation, for survival, muscle strength and neuromuscular degeneration. This strain series includes several new alleles that incorporate variable numbers of sequences from the human survival of motor neuron 2 (SMN2) genedirectly into the mouse Smn1 locus. These strains provide critical preclinical models for drug testing by pharmaceutical companies.
Preterm birth: In collaboration with the March of Dimes and its funded investigators, we are pursuing the genetic regulation of gestation time. GRS scientists with expertise in mouse genetics and MDs who see clinical patients daily are working together to identify the genetic contribution to differences in gestation time that could lead to preterm birth.
Other collaborative projects currently underway focus on aneuploidy, cardiac development, Charcot-Marie-Tooth (CMT)disease, Cystic Fibrosis, Friedreichs ataxia, and high throughput sequencing of the mouse genome.