Wild-derived inbred mice

Definition and Applications

Wild-derived inbred mice are descendants of captured wild mice and often originate either from only one pair or trio. The large number of genetic differences between wild-derived and common inbred mice makes them valuable tools for evolution and systematics research and makes progeny from crosses between them and common inbred strains especially useful for genetic mapping. Additionally, because several wild-derived inbred strains naturally carry Robertsonian chromosomes, they are useful for studying tissue or cell markers for chimeras and transplantation, producing chromosome-specific trisomies, and FISH gene mapping.